Chetan Subhash Khade, Dr. Ganesh Deshmukh, Ketki Bhurkunde, Crispin Fernando
Pellets possess major therapeutic and technical advantages which makes them as an exceptionally useful dosage form Multiparticulate system is a promising system for oral drug delivery. Palletization is a process in which fine powders or granules are converted into free-flowing semi-spherical units called as pellets. There are different palletisations techniques available to prepare drug loaded spherical particles. Extrusion Spheronization is one of them and utilized in formulation of pellets. Limitations which are related to bioavailability and site-specific drug delivery can be overcome by this technique. The other techniques for pelletization are namely hot melt extrusion, freeze pelletization, cryopelletization have been discussed along with formulation requirements for the process, parameters affecting pelletization. Keywords: Pellets, Multiple unit dosage form, Spheronization, Extrusion, Modified release, sustained released.