Dr. Sumreen Bibi, Dr. Shaffuq Saleem, Dr. Arooma Zainab
Introduction: The liver injury is reported often as secondary to hypersensitivity drug allergy resulting in centrizonal cholestasis, progressing to hepatocellular damage. In severe reactions, bile duct injury has been reported. Objectives of the study: The main objective of the study is to find the role of Amoxicillin with the comparison of Clavulanate for drug induced liver injury in hepatic patients. Methodology of the study: This case control study was conducted at Allama Iqbal Memorial Teaching Hospital, Sialkot during January 2019 to June 2019. For this purpose we select the 30 patients who was suffering from chronic hepatic injury due to the excessive use of drugs especially Amoxicillin and Clavulanate. Results: We analyzed 30 cases matched to controls. Seven cases were exposed to amoxicillin (adjusted OR 1.69, 95% CI 0.72-3.98) and 23 cases to co-amoxiclav (adjusted OR 3.00, 95% CI 1.76-5.40). Conclusion: It is concluded that compared to amoxicillin alone, amoxicillin +clavulanic acid doubles the risk of serious acute liver injury, in agreement with most studies on DILI.