::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CORRELATION OF PSA IMMUNOSTAIN WITH GLEASON’S GRADING AND SCORING SYSTEM OF PROSTATIC CARCINOMA

AUTHORS:

Dr. Asmara Rasheed, Prof. Dr. Nasir Mahmood Chughtai, Dr. Muhammad Sami Iqbal

ABSTRACT:

Background: Prostatic carcinoma is the commonest malignancy in males above the age of sixty-five years. Prognosis of prostatic carcinoma depends on clinical status and grade of tumor. Gleason scoring system for tumor differentiation is more superior to other systems. The prostate cancer clinical sequence is flexible and at cannot adequately be identified by histological procedures only. Introducing of immuno-stains to the study of prostatic carcinoma has so long as an additional sub-classification of prostatic carcinoma, appreciation of definite cell varieties and dissimilar categories of carcinoma prostate. Objective: To assess immune histochemical staining of tissue prostate specific antigen in prostatic carcinoma using Gleason’s grading and scoring system. Material and Methods: It is a descriptive cross-sectional study conducted at Sheikh Zayed Hospital, Lahore for 6 months. Ninety cases of prostatic adenocarcinoma were collected from the Department of Urology and General Surgery, in order to assess tissue prostate specific antigen expression on prostatic adenocarcinoma and its correlation with the Gleason’s grading and scoring System. Ninety biopsies of prostate CA with the histological diagnosis of adenocarcinoma were included. Results: The mean age of patient was 66.40±5.78 years. Gleason’s score 3 was noted in 5 (5.6%) cases, score 4 in 24 (26.7%) cases, score 5 in 1 (1.1%) cases, score 6 in 24 (26.7%) cases, score 7 in 6 (6.7%) cases, score 8 in 17 (18.9%) cases, score 9 in 5 (5.6%) cases and score 10 in 8 (8.9%) cases. Staining intensity was 0 in 6 cases, (+) in 19 cases, ++ in 37 cases and +++ in 28 cases. Staining intensity showed strong association between tumor differentiation (p <0.05). Similarly, Gleason score showed strong association with staining intensity (p <0.05). Conclusion: In conclusion, the study shows correlation of PSA immune stain with Gleason’s grading and scoring system of prostate carcinoma showing good correlation. Key Words: Prostate cancer, adenocarcinoma, PSA, Gleason score.