::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ANALYSIS OF CONDITIONS ASSOCIATED TO CHRONIC UROTHELIAL INFLAMMATION

AUTHORS:

Dr. Komal Ashfaq, Dr. Nazish Anwar, Dr. Najm-ul-Sehar

ABSTRACT:

Recurrent urinary tract infection (UTI) is a very bothersome and a popular problem in the urogynecology clinical practice. According to the IUGA/ICS joint report on the terminology for female pelvic floor dysfunction, recurrent UTI is defined as at least three symptomatic and medically diagnosed UTI in the previous 12 months. The basic aim of the study is to analyze the conditions associated to chronic urothelial inflammation in local Pakistani population. This cross-sectional study was conducted in Bahawal Victoria Hospital, Bahawalpur during June 2019 to December 2019. The sample size was 50 patients from both genders. Bladder symptoms and lower urinary tract conditions were investigated. The analytical variables included gender, CKD or ESRD, anuria or nonanuria, history of UCC of the bladder, the presence of recurrent UTIs, and clinical symptoms of bladder pain. The analysis of data shows the differences in urodynamic variables between the control subjects and the ESRD/CKD patients. Overall, the ESRD/CKD patients had significantly lower FS, US, and CBC than did the controls. Patients with ESRD/CKD with DU had significantly lower FS, CBC in ESRD/DU patients with BO. It is concluded from our study that chronic inflammation, urothelial cell apoptosis and impairment of barrier function of urothelial cells could be the underlying pathophysiology of recurrent UTI in women.