Mohsin Javeed, Haseeb Ahmad, Friha Tufail
Objective: To examine the clinical impact of the alterations in the levels of glycosylated hemoglobin of diabetics on the CHD (Chronic Heart Disease) and HTN (Hypertension). Methodology: Division of total 196 patients carried out in two groups; control group comprising 96 patients without diabetes and patient group with one hundred diabetics. The comparison of the biochemical indexes of the patients of both groups was carried out. Moreover, the division of the patients of the observation group was carried out in different sub-groups in accordance with the availability of hypertension and chronic heart disease and the comparison of the HbA1c level was carried out in various sub-groups. Results: There was no significant difference in the levels of TC (Total Cholesterol), TG(Triglyceride) and LDL-C (Low-Density Lipoprotein Cholesterol) of the patients in both groups (P>0.050). However, level of HDL-C (High Density Lipoprotein-Cholesterol) of the patients in observational group was much low as compared to the subjects of control group (P<0.050). SBP & DBP (Systolic Blood Pressure & Diastolic Blood Pressure), FPG (Fasting Plasma Glucose), FI (Fasting Insulin) and values of hs-CRP (High-Sensitivity C - reactive protein) and level of HbA1c of patients in observational group were significantly high in comparison with the group of controls (P<0.050). HbA1c level of the hypertension patients was much higher as compared to the patients without hypertension (P<0.050). HbA1c level of the patients suffering from chronic heart disease was significantly higher as compared to the patients without chronic heart disease (P<0.050). The results of the Pearson correlation analysis stated that HbA1c level of the patients in group of diabetics was in strong correlation with systolic and diastolic blood pressures and CRP level (P<0.050). Conclusion: HbA1c level of the patients suffering from diabetes was in a strong association with the BP and CRP level. HbA1c level can predict the rate of occurrence of hypertension and chronic heart disease. Identification of the values of glycosylated hemoglobin is much vital in the screening of the patients present with hypertension and chronic heart disease. KEYWORDS: Diabetics, Blood Pressure, Screening, Hba1c, Hypertension, Chronic Heart Disease, Systolic, Diastolic, Plasma, Fasting Plasma Glucose.