E. Satheesh Kumar* and Venkatesh Kyavars
The present study is carried out with an aim to prepare and evaluate the floating tablets of Ranitidine Hydrochloride. The floating tablets were based on effervescent approach using sodium bicarbonate a gas generating agent. The FTIR studies show that there is no incompatibility between polymers and excipients used in the formulation. The tablets were prepared by Direct compression method. The effect of polymers such as HPMC K4M, Chitosan, Guar gum and Carbopol 934 on drug release profile was evaluated. The effect of HPMC K4M, Chitosan, Guar gum & Carbopol 934 on floating properties were also investigated. The result of In vitro dissolution study showed that the drug release profile could be controlled by increasing the concentration of HPMC and Chitosan. The formulation containing HPMC K4M and Chitosan showed 85.42±0.42 drug release at the end of 8 hours. Hence, Floating drug delivery system of Ranitidine Hydrochloride is prepared to increase the bioavailability of the drug and prolonged therapeutic effect. Keywords: Floating drug delivery system, HPMC, Chitosan, Ranitidine Hydrochloride, Controlled release.