::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

CLINICAL ASSESSMENT OF ROXITHROMYCIN IN TREATMENT OF ACNE VULGARIS; DAILY VERSUS ALTERNATE DOSE COMPARISON

AUTHORS:

Dr. Atia Batool, Dr. Zareen Arshad, Dr. Maryum Yousaf

ABSTRACT:

Aim: Roxithromycin, one of the latest macrolides, has been shown to be effective against acne in some clinical trials. These trials have been done with once or twice daily dosage schedules. In another closely related macrolide, the effectiveness of azithromycin has been demonstrated on alternative days, we conducted this trial to see whether an alternate day regimen of roxithromycin gives comparable results with those of daily regimen or not. Place and Duration: In the Dermatology department of Bahawal Victoria Hospital (BVH) Bahawalpur for six months duration from October 2019 to March 2020. Methods: The study included 140 patients who were randomly divided into two groups. Patients in group I were treated with 300 mg of roxithromycin once daily for eight weeks. Those in Group II used 300 mg of roxithromycin for alternating days for eight weeks. Results: Results could be evaluated in 125 patients, with 15 patients lost to follow up. Out of 60 patients in Group-I, 32% showed good (>50%) improvement, 57% moderate (25-50%) and 10% slight (<25%) improvement. Of the 65 evaluable patients in Group-II, 28% showed good, 55% moderate and 14% slight improvement. Using chi-square tests the difference between the results of the two groups was found to be insignificant (p>0.5). Side effects noted were transient and were nausea, slight gastric upset and diarrhea in 10% patients in Group-I and 4.6% patients in Group-II. Conclusion: As a result, it was found that the alternative day dosing system is almost as effective, but safer and more economical than the day dosing system. Keywords Roxithromycin, acne vulgaris