::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ANALYSIS OF THE ETIOLOGY OF ACUTE HEPATITIS IN ADULT PATIENTS OF LAHORE ADMITTED IN THE INFECTIOUS DISEASES UNIT

AUTHORS:

Dr. Shagufta Khan, Dr. Syed Rehan Hayder Naqvi, Dr. Rimsha Masoud

ABSTRACT:

Objective: To investigate the etiology of acute hepatitis in adult patients admitted in a hospital. Methods: The study included all acute hepatitis patients admitted in the Infectious Diseases Unit of Jinnah Hospital, Lahore for a duration of One Year from February, 2019 to January, 2020 . Various viral markers were used to establish the diagnosis of acute hepatitis which included anti HAV IgM, HBsAg, Anti HBc IgM), anti HCV IgG and anti HEV IgM by ELISA. In hepatitis C positive cases HCV RNA was also done to confirm acute HCV. Liver function test were done by Hitachi 912 machine. Results: A total of 165 cases with acute hepatitis were admitted in the hospital during the study period. The specific etiologic diagnosis could be made in 122(74%) patients and of these acute hepatitis E was found in 40%, HAV in 18.7%, HBV in 11.5%, HCV 1.2%, and combined infection 4.2%.Overall, HEV accounted for 54% of acute viral hepatitis. The mean age of the patients with HAV infection was significantly younger than patients with HEV and HBV, p value <.0001 and <.0002 respectively. Prothrombin time was longer in HAV infection than HBV and HEV, (p<.01 and <.02) respectively. However, there were no significant differences in serum bilirubin and transaminases concentration among different groups. Conclusion: The present study showed that about 60% of the acute viral hepatitis is water borne and can be easily controlled with improving sewage and water distribution and personal hygiene.