Dr. Zia Shahid, Dr. Ataf Shumail, Dr. Sajeela Akhtar
Purpose: Gastroesophageal reflux disease (GERD) has become the most common gastrointestinal disorder in clinics. Gastric acidity due to impaired gastroesophageal junction will affect the esophageal epithelium. Aim of the study: To investigate the relationship between circulating adiponectin and GERD levels in patients undergoing upper endoscopy. Place and Duration: In the Gastroenterology Department of Services Hospital Lahore for one year duration from March 2019 to March 2020. Patients and methods: Data from 40 patients with GERD and 30 healthy controls and endoscopy were collected. Calculated weight, height, waist circumference, body mass index. A lipid profile and adiponectin were done. Results: The results showed a strong negative correlation between adiponectin and age, height, weight, BMI, waist circumference, waist to hip ratio, cholesterol, triglycerides and LDL. There is only a positive correlation between adiponectin and HDL and LDL / HDL (+0,214 and +0,014 respectively). Conclusions: This study emphasizes that impaired circulation of intestinal adiponectin hormones plays a role in the pathogenesis of GERD and may be susceptible to Barrett's esophagus. Key words: adiponectin, GERD, lipids.