Dr Naila Shoukat, Dr Jafir Wakeel, Dr Amel Amjad Buttar
The coronavirus illness 2019 (COVID-19) episode is the significant danger to individuals. Lung injury has been accounted for as the significant result of COVID-19 disease. Be that as it may, liver harm has likewise been considered to happen in extreme cases. Our current research was conducted at Lahore General Hospital, from April 2019 to March 2020. The current meta-examination of review contemplates remained accomplished to sum up accessible discoveries on the association among liver injury also, seriousness of COVID-19 contamination. Online databases including PubMed, Scopus, Web of Science, and Cochrane Library were looked to distinguish important distributions up to 3 March 2020, utilizing important watchwords. To pool information, a fixed-or arbitrary impacts model was utilized relying upon the heterogeneity among contemplates. Besides, distribution predisposition test and affectability investigation were additionally applied. Altogether, 20 review concentrates with 3435 COVID-19 contaminated cases (extreme patients, n =1457; mellow cases, n =1977), remained remembered for this meta-analysis. Higher serum levels of aspartate aminotransferase (weighted mean contrast, 9.85 U/L; 96% certainty span [CI] 6.98 to 12.72; P <0.002), alanine aminotransferase (weighted mean contrast, 8.36 U/L; 96% CI, 5.78 to 8.94; P <0.002), all out bilirubin (weighted mean contrast, 3.31 mmol/L; 96% CI, 2.25 to 4.37; P <0.002), in addition lower serum levels of egg whites (weighted mean contrast, 6.25 g/L; 96% CI, 8.23 to 4.28; P <0.002) remained related with a noteworthy increment in seriousness of COVID-19 contamination. The rate of liver damage, as evaluated by serum analysis (aspartate aminotransferase, alanine aminotransferase, complete bilirubin, in addition egg whites levels), is by all accounts higher in cases through extreme COVID-19 contamination. Keywords: Liver Injury, seriousness, covud-19.