::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ROLE OF ANTIBIOTICS FOR ADULTS WITH ACUTE CHOLECYSTITIS

AUTHORS:

Dr Muhammad Ali Hussnain, Dr Talha Jahangir, Dr Muhammad Shoaib

ABSTRACT:

Introduction: Acute cholecystitis is the most common complication of cholelithiasis. In fact, ≥ 95% of patients with acute cholecystitis have cholelithiasis. Objectives: The main objective of the study is to analyse the Role of Antibiotics for adults with acute cholecystitis. Material and methods: This cross-sectional study was conducted in Rashid Latif medical college, during June 2019 to January 2020. All adult patients who presented to our hospital with symptoms of right upper quadrant pain and diagnosed to have acute calculus cholecystitis on the basis of clinical and radiological signs and underwent cholecystectomy were included. Acute calculus cholecystitis was finally confirmed on the basis of histopathology. Results: The overall mean age was 48.9±14.1 years. Empiric antibiotics were used in 349(97%) patients, including combination therapy in 182(52.1%) patients and monotherapy in 167(47.9%) patients. Most of the patients with severe acute cholecystitis received combination therapy, while monotherapy was more frequently used in patients with mild and moderate acute cholecystitis. Besides, 201(56.5%) patients also received antibiotics on discharge, including 55(38.7%) in grade I, 122(65.9%) in grade II and 24(82.8%) in grade III. Conclusion: It is concluded that early laparoscopic cholecystectomy is the best therapeutic approach for AC and that post-operative antibiotics are not necessary in cases of uncomplicated cholecystitis.