::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A RANDOMIZED, CONTROLLED TRIAL OF TOTAL KNEE REPLACEMENT

AUTHORS:

Dr Jawaria Nafees,Dr Iram Zehra,Dr Waqas Ahmad Khalid.

ABSTRACT:

The most effective treatment for end stage osteoarthritis is known as total knee replacement therapy. The statistics of total knee replacements have been increased rigorously in the United States from 31.2 per 100,000 person-years. This randomized controlled trial including patients with knee osteoarthritis who were eligible for unilateral total knee replacement, to investigate whether total knee replacement followed by a 12-week nonsurgical-treatment program that consists of exercise, education, dietary advice, use of insoles, and pain medication provides greater pain relief and improvement in function and quality of life than do nonsurgical treatment alone. The results indicate that total knee replacement when followed by non-surgical treatment shows effective outcomes whereas only pain relief therapy and improving quality of life 12 months in patients with moderate-to-severe knee osteoarthritis who are eligible for unilateral total knee replacement is not favorable. However total knee replacement has its ultimate consequences which are not favorable at all and participants who were assigned to get nonsurgical treatment alone were not underwent total knee replacement before the 12-month follow-up and clinically well improvements.