- CODEN : IAJPBB
- issn 2349-7750
TITLE:
MEASUREMENT OF ARGINASE ACTIVITY IN ERYTHROCYTES IN NEWBORNS AND CHILDREN AND ITS CORRELATION WITH PLASMA AMMONIA CONCENTRATION
AUTHORS:
Ali Nawaz, Dr Maryam Irshad, Dr. Alina Goheer
ABSTRACT:
Background- Arginase an enzyme of urea cycle which catalyzes the cleavage of L-arginine to urea and L-ornithine. This is an inherited genetic disorder. In blood elevated level of ammonia refers the condition of hyperammonemia which is protein degradation product. In blood lack of arginase enzyme can result in excessive accumulation of nitrogen in form of arginine and ammonia. Methods- In this study, along with plasma ammonia concentration erythrocyte arginase activity is measured in children and newborns. In this study 133 subjects were selected and based on ammonia level these all were divided into two groups. In group 1 (92) patients were kept who had normal level of ammonia whereas in group 2 number of patients were 41 who had high level of ammonia. Results- It was found that in high level of ammonia group there was significant decrease in arginase group as compared to the normal ammonia group. In both groups between ammonia and arginase negative correlation was observed. Conclusion- It was concluded that the reason behind hyperammonemia can be the deficiency of arginase. Therefore, in children, infants, newborns deficiency of arginase can be detected through the screening of arginase activity. Keywords: Newborn screening, urea cycle, hyperammonemia, arginase
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Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
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