- CODEN : IAJPBB
- issn 2349-7750
TITLE:
CONSEQUENCE OF ORAL TIZANIDINE ON PROTRACTION OF INTRATHECAL LIDOCAINE
AUTHORS:
Dr Kinza Saif, Dr Rabiya Fatima, Dr Iqra Aziz
ABSTRACT:
Objective: In order to prolong the duration of intrathecal lidocaine, various drugs are used along with it. Due to the promising effects of tizanidine on central nervous system, it can be assumed that tizanidine can have a positive effect on increasing the anesthesia duration too. Thus, we aimed to investigate the effect of oral tizanidine on the duration of lidocaine spinal anesthesia. Methods: This double-blind clinical trial was conducted on 40 male patients waiting for elective leg surgery with the age range of 20-60 years in the Anesthesia Unit II department of Mayo Hospital Lahore for one-year duration from May 2019 to May 2020. We used simple random sampling and our participants were assigned into 2 groups (placebo and oral tizanidine receivers). Spinal anesthesia with 1 mg/kg of hyperbaric lidocaine 5% was performed in both groups. In tizanidine group, patients received 4 mg of oral tizanidine one hour before spinal anesthesia. Sensory block was examined by pin prick test and all anesthetic duration including start block until reduction of sensory level was calculated at 2 lower dermatomes. Results: Findings showed that oral tizanidine compared to placebo can cause a 10-15minute increase in patients’ lidocaine spinal anesthesia. Therefore, the average anesthesia time for tizanidine group increased meaningfully (P= 0.03). In addition, tizanidine can sedate patients during surgery (P= 0.00) or in recovery (P= 0.003). Conclusion: Based on the results, tizanidine increased the duration of lidocaine so oral tizanidine can be used to prolong the duration of lidocaine spinal anesthesia. Keywords: Tizanidine, Intrathecal lidocaine, Spinal anesthesia
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NLM ID:101711216 [Serial]
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