::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

LEVELS OF LIPIDS AND SERUM GAMMA-GLUTAMYL TRANSPEPTIDASE IN YOUNG ADULT PATIENTS OF NON-COMPLICATED ESSENTIAL HYPERTENSION

AUTHORS:

Dr. Nouman Ikram, Dr. Osman Shah, Dr. Maleeha Saleem

ABSTRACT:

Introduction: Gamma-glutamyl transpeptide, which was initially used as an indicator of alcohol consumption, is now seen as a sensitive marker of subclinical inflammation. Recent clinical studies have shown its association with blood pressure and lipid profile. Because GGT lowers glutathione, the antioxidant GGT can be considered a pro-inflammatory marker that plays a role in aerogenesis and hypertension. The aim of this study was to determine the levels of lipids and serum gamma-glutamyl transpeptidase in young adults with uncomplicated essential hypertension. Place and Duration: In the Medicine department of District Headquarters Hospital, Rawalpindi for one-year duration from April 2019 to March 2020.Materials and methods: 65 subjects with Essential hypertension and 50 age and sex matched healthy controls both male and female between 18-50 years of age were recruited from General Medicine department. Serum GGT was measured by calorimetric kinetic assay. Fasting Serum Triglycerides, Total Cholesterol and HDL cholesterol by standard enzymatic procedures and LDL cholesterol by Fried-wald equation.Results: GgT significantly increases in cases of hypertension (mean SD 64.2-18.62 IU/L) compared to controls (SD mean 26.20-8.91IU/L) (P value 0.001). GGT is significantly associated with systolic blood pressure (r-0.26 p