::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

HYALURONIC ACID VERSUS PLATELET-RICH PLASMA: A PROSPECTIVE, DOUBLE-BLIND RANDOMIZED CONTROLLED TRIAL COMPARING CLINICAL OUTCOMES.

AUTHORS:

Dr Waqas Ahmad Khalid,Dr Kiran Javed,Dr Aisha Iftikhar

ABSTRACT:

Introduction: The use of platelet-rich plasma (PRP) for treating osteoarthritis (OA) has shown mixed clinical results in randomized controlled trials as opposed to hyaluronic acid (HA), an approved non-chirurgical treatment for symptomatic OA. Anti-inflammatory effect on the intraarticular environment has been demonstrated by biological study of PRP. Methods: In total, 111 patients received a series of PRP leukocyte-poor injections or ultrasound guidance injections with symptomatic unilateral knee OA. Until diagnosis and at a time of 4 points over a span of 1 year, clinical data had been obtained. In addition, Synovial Fluid has been obtained before treatment and 12 and 24 weeks after treatment for proinflammatory and anti-inflammatory marker study. Multiple steps were used to evaluate outcomes: (1) WOMAC pain subscale; (2) IKDC subjective knee assessment, VAS pain visual comparison, and Lysholm knee score; and (3) difference of biochemical intraarticulary marker concentrations. In this study, the effects were assessed by several different measures. Conclusion: We notice no difference between HA and PRP at any time point in the primary outcome measure: the patient-reported WOMAC pain rate. Certain outcomes reported by patients have seen major changes, with PRP over HA findings favored. In the past, the propensity to decrease in two proinflammatory cytokines has been shown to indicate that the anti-inflammatory properties of PRP are able to lead to symptom improvement.