Dr Natasha Masood,Dr Aisha Iftikhar,Dr Kiran Javed
In 1849 Addison elucidate an entity with conditions such as pallor appearance, weakness, and consistently decline heath. Thereafter multiple advances have brought the clue of this issue that PA is characterized through the impaired absorption of cobalamin. It is an eminent cause of cobalamin deficiency globally. This review mainly focused on the current understanding of the disorder it’s a neurological, hematological, and biochemical presentation with emphasis on diagnosis, treatment, and monitoring strategies. We hereby, review the diagnostic approach by deeming the present performance and constraint with current diagnostic tools used to find out the cobalamin status and identification of autoimmune chronic atrophic gastritis. Lifelong treatment is necessary for the patient of PA along with the cobalamin replacement treatment. The enteral and parenteral supplements used for the current treatment of PA by comparing with efficacy and tolerability.