- CODEN : IAJPBB
- issn 2349-7750
TITLE:
DIAGNOSTIC IMPORTANCE OF MEAN PLATELET VOLUME IN ANKYLOSING SPONDYLITIS AS A DISEASE ACTIVITY PREDICTOR
AUTHORS:
Dr Ramsha Mehmood, Dr Aisha Abrar, Dr Ahmed Naeem
ABSTRACT:
Introduction: Ankylosing spondylitis (AS) is a chronic progressive inflammatory rheumatic disease that leads to a significant reduction in quality of life. Average platelet volume (MPV) is part of a complete blood test (CBC) and is associated with platelet function and activation. Aim: To evaluate the diagnostic value of MPV in patients with AS and to assess its relationships with disease activity index. Place and Duration: In the Rheumatology department of Allied Hospital Faisalabad for one year duration from April 2019 to March 2020. Patients and methods: A total of 100 patients with AS (78 men: 22 women) were diagnosed according to modified New York classification criteria for AS, and 146 (99 men: 47 women) healthy subjects were selected for age and gender as controls. Demographic data, disease activity scores were measured using ankylosing spondylitis activity index (BASDAI), history, C-reactive protein (CRP), erythrocyte sedimentation rate (ESR) and MPV. Results: The mean age of patients was 38.0 ± 9.0 years and controls 35.8 ± 8.3 years. Men constituted 78% of patients and 67.8% of controls. The mean BMI was 28.3 ± 5.5 kg / m2 in patients and 28.6 ± 3.8 kg / m2 in the control group. There were no statistically significant differences in age, sex and BMI between patients and the control group (p> 0.05). MPV was significantly higher in patients with AS compared to healthy controls (9.215 ± 1.57 vs. 7.753 ± 0.86). MPV had a good ability to distinguish between active AS and inactive patients with AS. The optimal cut-off point was less than 9.9. MPV had the highest accuracy (79%) with a high specificity of 86.8%, the positive predictive value (PPV) in the 50% initial test was 84.9%, and in the 90% preliminary test was 98.1% with a sensitivity of 74.2% and the negative predictive value (NPV) at the 10% initial test was 96.8%. MPV had a significant positive correlation with disease activity. Increased MPV will increase disease activity. Conclusion: MPV was significantly higher in patients with AS than in the control group and was directly correlated with ESR, CRP and BASDAI. Key words: mean platelet volume, ankylosing spondylitis, disease activity, BASDAI
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Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
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IP Indexing Impact Factor: 2.76
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