::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

PRESENT THE SIGNIFICANCE OF THE DISCOVERY OF DUCHENNE MUSCULAR DYSTROPHY BEFORE BIRTH AND TO SHOW IMPACT OF CHANGES IN THE QUALITY OF DMD ON GESTATION OUTCOMES

AUTHORS:

Dr Muhammad Usman Khan, Dr Islam, Dr Tabish Ramzan

ABSTRACT:

Aim. To present status of the discovery of Duchenne muscular dystrophy before birth in addition to show impact of changes in quality of DMD on gestation outcomes. Methods. Authors thoughtfully assessed 92 pregnancies in 82 persons who discussed to Jinnah Hospital, Lahore for prenatal DMD analysis between January 2000 and December 2015. Pre-birth analysis techniques (chorionic villi examination (CVS): 67, amniocentesis (AC): 24) remained analyzed for test outcomes, segment highlights, and obstetric results of pregnancies. Woman embryos were separated into 2 sets rendering to DMD position (sound or carrier) to comprehend impact of changes in DMD quality on obstetric results. Results. Nine outbreaks that were positive on prenatal analysis remained finished. Here was not any measurable significant contrast among CVS and AC sets in relations of study factors. Here remained 48 male (52.7%) and 43 female (49.5%) babies. Seventeen of female babies remained carriers (35.9%). The mean birth weight values were significantly lower than those of the carriers. Conclusion: Pregnancies at danger for DMD would be tried before birth to avoid impact of the illness on families also DMD carrier babies had obstetrical results such as DMD negative woman outbreaks. Keywords: Duchenne Muscular Dystrophy, Before Birth, Gestation Outcomes.