::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

SEX CHROMATIN CONTENT AS THE OBJECTIVE WAY TO ASSESS THE RISK OF ENDOMETRIAL MALIGNANCY WHEN USING SILVER-CONTAINING INTRAUTERINE DEVICES

AUTHORS:

Petrov Yu.A and Kupina A.D.

ABSTRACT:

Aim. The purpose of this study was to assess the content of sex chromatin in the endometrium of women using silver-containing IUDs for the period of 1 to 7 years. Materials and methods. The study involved 460 women aged 23-57 years. Scrapings of the uterine mucosa were examined during application or after removal of silver-containing IUDs to study the content of sex chromatin and the peculiarities of the endometrium’s mitotic regime at different periods of application of silver-containing IUDs. Scrapings were obtained on days 8-10 or 19-23 (middle stage of proliferation and secretion, respectively) of the menstrual cycle. Sections of the endometrium were processed according to Feelgen and for more accurate identification of figures with mitosis-iron hematoxylin according to Heidengin. Results. During the study it was found out that the content of sex chromatin in the cells of the endometrial glands did not undergo significant changes, but there was the increase in its content in the endometrium of women who used silver-containing intrauterine devices for up to 12 months. Keywords: silver-containing IUDs, contraception, sex chromatin, endometrial malignancy, mitotic activity.