::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

EFFECT OF MAGNESIUM SULPHATE COMBINED WITH NIFEDIPINE FOR THE TREATMENT OF HYPERTENSION INDUCED BECAUSE OF PREGNANCY

AUTHORS:

Dr Alia Kanwal, Dr Afifa Ashraf

ABSTRACT:

Objective: This research work was carried out to examine the influence of magnesium sulfate in combination with Nifedipine for the treatment of PIHS (Pregnancy-Induced Hypertension Syndrome). Methodology: A sum of 180 pregnant females present with Pregnancy-Induced Hypertension Syndrome who got admission in our institute from May 2019 to June 2020 were separated randomly into CG (Control Group) and OG (Observation Group) with 59 patients in each. We treated the patients of Observation Group by magnesium sulfate combined with Nifedipine, whereas we treated control group with only magnesium sulfate. We compared level of Apelin, therapeutic effect, viscosity of blood, urinary protein, serum LIF (Leukemia Inhibitory Factor), BP (Blood Pressure) and UARI (Umbilical Artery Resistance Index) between both groups. Results: The rate of effectivity of Observation Group was 94.90%, which was higher than 83.10% effectivity rate of the patients of control group, and this difference was much significant statistically (P <0.050). Level of decrease of diastolic & systolic Blood Pressure in Observation Group was much better as compared to the patients of control group and this difference was also significant statistically (P<0.050). Reduction in the viscosity of blood, urinary protein, Umbilical Artery Resistance Index and S/D in the patients of Observation Group was higher than that of the patients of control group and this difference was also significant statistically (P<0.050). Improvement in the levels of apelin and serum Leukemia Inhibitory Factor in the patients of Observation Group was much better as compared to the patients of control group and we found this difference significant statistically (P<0.050). Conclusion: Treatment of Pregnancy-Induced Hypertension Syndrome with the help of magnesium sulfate in combination with Nifedipine has much better effect and it can efficiently control Blood Pressure, edema, proteinuria. It is also better for the protection of kidneys. KEYWORDS: Pregnancy-Induced Hypertension Syndrome, Viscosity, Blood Pressure, Systolic, Diastolic, Proteinuria, Magnesium Sulfate, Observation Group, Control Group, Apelin.