::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ALTERATIONS IN THE SERUM LIPOPROTEINS OF PRIMI-PAROUS FEMALES SUFFERING FROM ECLAMPSIA AND ITS COMPARISON WITH NORMAL PREGNANT FEMALES

AUTHORS:

Dr Afeen Malik, Dr Maida Hassan, Dr Alishba Saeed

ABSTRACT:

Objective: To assess the alterations in the serum lipoproteins in primi-parous females suffering from eclampsia and its comparison with the normal healthy females having pregnancy. Methodology: This transverse research work carried out on 65 Primi-parous patients of eclampsia and 21 pregnant females with normal blood pressure in the Mayo Hospital, Lahore. The record of the history of every female was maintained on well-organized questionnaire. Utilization of standard methods carried out for the measurement of the BP (Blood Pressure). We collected a blood sample of five milliliter from every participant to examine the level of serum lipoproteins. SPSS V.20 was in use for the statistical analysis of the selected information. P value <0.050 was statistically significant. Results: Average age of hypertensive females was 23.20 ± 0.52 years whereas average age of the healthy controls was 23.90 ± 1.16 years. We found a significant difference in the level of lipoproteins. Women present with eclampsia had 28.80%, 29.50%, 31.10%, 32.90% and 65.30% high LDL-C (Low density Lipoprotein-Cholesterol), TG (Triglycerides), ratio between TC (Total Cholesterol) and HDL-C (High Density Lipoprotein-Cholesterol), ratio of LDL-C to HDL-C and ratio of TG and HDL-C correspondingly as compared to the group of healthy controls. The concentrations of HDL-C, ratio between HDL-C and VLDL-C and level of apolipoprotein A-1 were 26.90%, 56.60% and 27.90% respectively, less in the group of patients as compared to the group of healthy controls. Conclusion: The findings of this research work shows that assessment of the concentration of serum lipoprotein in the duration of antenatal period can be beneficial in early identification and prevention of the development of eclampsia. KEY WORDS: Primi-Parous, Pregnancy, Assessment, Alterations, Pressure, Eclampsia.