- CODEN : IAJPBB
- issn 2349-7750
TITLE:
EVALUATION OF HYPOGLYCEMIC AND HYPOLIPIDEMIC ACTIVITIES OF ZIZYPHUS JUJUBA
AUTHORS:
Dr . Dhanapal Venkatachalam
ABSTRACT:
Objective: The present study was designed to evaluate the hypoglycemic and hypolipidemic activity of methanolic extract of zizyphus jujuba leaves in normal and streptozotocin inducing diabetic rats. Zizyphus jujuba Lam. is also called as Baer tree, belongs to the family Rhamnaceae. It is used primarily for its fruits. Jujube, a delicious fruit, is an effective herbal remedy improving stamina and muscular strength and aids weight gain, strengthens liver function and increases immune system resistance. Methods: The dried bark was powdered and extracted with various solvents by successive soxhlet hot extraction process with increasing order of polarity. On phytochemical investigation, the methanol extract and aqueous extract has shown steroids, flavonoids and tannins. The zizyphus jujuba was reported for the many of biological activity, and hypoglycaemic activity of the same has not been reported so far. Streptozotocin is used to induce diabetic in rats and the blood lipid levels were estimated using commercial kits available in the market. The methanolic extract of Zizyphus jujuba was administered at the doses 100mg/kg and 200mg/kg. Results : The methanolic extracts of Zizyphus jujuba 100mg/kg and 200mg/kg produced significant decreased p<0.01) in blood glucose level after 2,4 and 6 hour of treatment as compared to untreated diabetic rats respectively as 503±3.6, 163±3.9 (67±6.1) ,128±10.7 (74±2.2) ,125±5.4 (74±1.0) , 511±4.2, 262±4.5 (55±6.7), 205±2.8 (59±5.7) , 208±2.3 (58±4.8). The treatment of diabetic rats with (Group III) extracts for 3 weeks resulted in significant decrease of serum triglycerides, total cholesterol and LDL-c cholesterols as compared to untreated diabetic rats (Group II) and the values came down significantly (p<0.01 ) below those in the normal healthy control group . Conclusion: The results indicate that methanolic extract of Zizyphus jujuba in the dose dependent manner possess hypoglycaemic and hypolipidemic activity. Keywords: Zizyphus jujuba, Diabetic rats, Streptozotocin, hypoglycemic, hypolipidemic
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Approved Journal
NLM ID:101711216 [Serial]
Included in EuroPub database
ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
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IP Indexing Impact Factor: 2.76
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