::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

ASSOCIATION OF SERUM URIC ACID LEVELS WITH BLOOD PRESSURE IN NORMOTENSIVE, PREHYPERTENSIVE AND HYPERTENSIVE POPULATION

AUTHORS:

Dr. Marina Khan, Dr.Aneeqa Khalil, Dr. Ziarmal Khan

ABSTRACT:

Background: uric acid, a final metabolic product of purine breakdown, appears as an etiology in gout. Higher levels have also been associated with hypertension, cardiovascular morbidity and mortality. Few studies have been conducted, especially in India, to elucidate the relationship between uric acid and prehypertension. Objective: In this study, the relationship between serum uric acid levels and blood pressure in the normotensive, prehypertensive and hypertensive population was evaluated. Also, it should be checked whether there is an incremental increase in serum uric acid with an increase in blood pressure. Place and Duration: In the Medicine department of Holy Family Hospital Rawalpindi for one year duration from March 2019 to February 2020. Material and methods: Two hundred OPD patients meeting the inclusion and exclusion criteria and were included in the study population. A venipuncture was measured to collect venous blood to measure the blood pressure of each participant and then serum uric acid. According to the classification of the National Joint Committee 7, the participants were divided into 4 groups such as Normal, Prehypertension, Hypertension - Stage 1, Hypertension Stage -2. The data were analyzed to determine and confirm serum uric acid levels from four categories. The relationship of uric acid with blood pressure. Results and conclusion: A gradual increase in serum uric acid levels was observed with an increase in blood pressure. A strong positive linear correlation was observed between serum uric acid levels and mean arterial pressure (Pearson correlation coefficient r = 0.74; p <0.0001). Uric acid was associated with blood pressure in the prehypertensive population (r = 0.442). Serum uric acid levels are associated with prehypertension and hypertension and are strong independent predictors of cardiovascular mortality. Keywords: blood pressure, prehypertension, uric acid.