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TITLE:

STUDY TO DETERMINE THE RELATION OF SERUM HOMOCYSTEINE WITH CORONARY HEART DISEASE

AUTHORS:

Dr Farwa Yaqub, Dr Ziarmal Khan, Dr Marina Khan

ABSTRACT:

Background: CAD is the leading cause of death. Many factors are responsible for causing CAD, but 5 to 10 percent of CAD patients have none of the known risk factors. Changing the risk factor is an integral part of managing patients at risk or at risk of cardiovascular disease. Doctors looking after patients with cardiovascular disease should be aware of new risk factors. There are important relationships between established and new risk factors, and a better understanding of new risk factors can shed light on the pathogenic mechanisms of established risk factors. Objective: To investigate the relationship of homocysteine in patients with coronary heart disease. Study design: A Case control study. Place and Duration: In the Medicine and Cardiology department of Benazir Bhutto Hospital, Rawalpindi for one year duration from March 2019 to March 2020. Methods: This study was performed in 50 CAD patients and 50 people as a control group. All patients underwent standard clinical examination and blood draw for lipid profile and total fasting serum homocysteine test. Pearson chi-square test was used to evaluate statistical significance. A P value of less than 0.01 indicates that it is quite meaningful and a value below 0.05 is significant. Results: The threshold value of homocysteine used in this study was 17 micro mol / L. 43 patients (86%) in the case group showed high homocysteine and 12 patients (24%) in the control group showed homocysteine. increased. And here the p value is <0.001 and there is a relative risk of 19.45. It indicates that high homocysteine is statistically highly significant. Conclusion: The relationship between hyperhomocysteinemia and CHD was significant. Homocysteine values were higher in smokers and hypertensive patients. Key words: coronary heart disease, homocysteine.

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