::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

IMPACT OF AVERAGE PULSE-PRESSURE IN 24 HOURS ON CARDIAC FUNCTION AMONG PATIENTS PRESENTED WITH ISOLATED SYSTOLIC HYPERTENSION

AUTHORS:

Dr Muhammad Abdur Rehman, Dr Hafiza Saima Nawaz, Dr Hafiz Muhammad Adnan

ABSTRACT:

Objective: The aim of this study is to find out the impact of average pulse-pressure during 24 hours on cardiac function in elder patients with ISH (Isolated Systolic Hypertension). Methodology: In this research work, a total of 172 elder patients with Isolated Systolic Hypertension were studied. The purpose was to determine the average pulse-pressure with the monitoring of 24-hour ambulatory BP (Blood Pressure). We carried out the analysis of the cardiac function by nuclide pool imaging of cardiac blood. Results: There was negative correlation between 24-hours average pulse-pressure with the LVEF (Left-Ventricular Ejection Fraction (r= -0.46, P value < 0.01), and also with PFR (Peak Filling Rate) (r= -0.41, P value < 0.05). With the increase of the average pulse-pressure, the adverse effect on the cardiac function was noticed (P value < 0.01). Conclusion: 24-hours average pulse-pressure was a vital factor forecasting danger of cardiac dysfunction in elder age patients presented with Isolated Systolic Hypertension. KEY WORDS: Average Pulse-Pressure, Dysfunction, Isolated Systolic Hypertension, Blood Pressure, Ejection Fraction, Cardiac Function.