Dr Rabail Chaudhry, Dr Rizwan Rabbani, Dr Hafiz Saad Gulzar
Introduction and purpose: The incidence of diabetes has been recognized as an important medical problem worldwide in recent years. Magnesium deficiency has a negative effect on glucose metabolism and plays a key role in the development of diabetic complications. Hence, in the current study, we attempt to explore the level of magnesium ion and other biochemical markers in diabetic participants and to probe credential signs and the association between correlations with other biochemical markers studied in diabetic participants. Place and Duration: In the Medicine department of Pakistan Institute of Medical Sciences, Islamabad for one-year duration from February 2019 to February 2020. Subjects and methods: The study involved 80 participants, consisting of two groups: 40 healthy participants with normal blood sugar, 40 participants with type 2 diabetes: systolic blood pressure, diastolic blood pressure, glycated hemoglobin (HbA1c), fasting blood sugar (FBS), electrolyte profile (sodium, potassium and magnesium), blood urea nitrogen (BUN) and creatinine. In addition, lipid profile (total cholesterol, triglycerides and HDL cholesterol) was analyzed among diabetic participants and the relationship between serum magnesium levels and biochemical markers. Results: The participants with diabetes showed a significant change in FBS, HbA1c, BUN, creatinine, potassium and lipid profile compared to healthy participants, while participants with diabetes had sodium and magnesium levels compared to healthy participants. In addition, significant negative correlations with low serum magnesium and total cholesterol, HDL cholesterol and potassium were observed in diabetic patients. Conclusion: The alterations in lipid and electrolyte profiles observed in diabetic participants have great potential as a diagnostic tool in clinical practice especially hypomagnesaemia which was widespread among our diabetic participants and its correlations with other biochemical markers studied bears important clinical implications in achieving better control of the risk of diabetic complications. Key words: hypomagnesemia, diabetes, metabolism, correlation, lipids, electrolytes.