- CODEN : IAJPBB
- issn 2349-7750
TITLE:
RISK FACTORS AND CLINICOBACTERIOLOGICAL PROFILE OF EARLY ONSET NEONATAL SEPSIS
AUTHORS:
Dr Omar Asghar, Dr Qurrat ul Ain, Dr Muhammad Ahmad Khan
ABSTRACT:
Aim: To examine the risk factors and the clinical-bacteriological profile of early sepsis in newborns in the neonatal intensive care unit. Study Design: An observational / descriptive. Place and duration: In the Pediatric Unit II of Services Hospital Lahore for one year duration from March 2019 to March 2020. Material and methods: Relevant data of maternal risk factors was collected by taking history from mothers and consulting their case records. All infants developing clinical signs/symptoms of sepsis within 7 days of birth with positive blood cultures or supported by at least 2 laboratory parameters were diagnosed to have early onset neonatal sepsis (EONS). Data was analyzed by using SPSS version 19. Results: Among 2620 live births, 82 neonates were diagnosed as a case of EONS (Incidence 31.3/1000 live births), female to male ratio was 1:1.5 and maximum numbers of cases were in 0-3 day’s age group (54.8%). Majority of cases (60.9%) came from low socioeconomic group. Among neonates with EONS 48.8% & 75.6 were low birth weight and preterm respectively. Culture proven cases were only 17.1%. It is noted that among those who developed EONS 71.9% were neonates considered to be at risk for sepsis due to presence of maternal and neonatal risk factors. Prolonged rupture of membranes and foul smelling liquor were the most significant perinatal risk factors. The most important comorbidities were Hyperbilirubinemia (26.8%), metabolic acidosis (19.5%) & DIC (14.6%). In this study, the mortality rate was 7.3%. Klebsiella pneumoniae and Pseudomonas were the commonest causative organisms found in culture positive cases (42.8%). Conclusion: Information on the detection of risk factors and the clinical and bacteriological profile of EONS can lead to early diagnosis and rapid therapeutic interventions that minimize mortality and morbidity in newborns. Key words: early neonatal sepsis, risk factors, low birth weight, early
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NLM ID:101711216 [Serial]
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ICV 2015 - 61.16
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S.J Impact Factor:7.157
cosmos Impact Factor:4.153
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