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A STUDY ON LIVER ENZYMES IN HEPATITIS PATIENTS AND ROLE OF INTERFERON THERAPY AS A PROGRESSIVE TREATMENT IN PAKISTAN

Muhammad Saleh, Muhammad Sohail Ajmal Ghoauri, Yasooba Maqsood

Introduction: Hepatitis C is a worldwide health issue. Approximately, 71 million HCV cases are present in the world. Viral hepatitis claimed more annual deaths than HIV or malaria. It is the 7th leading cause of deaths worldwide. Objective of the study: The main objective of the study is to analyze the liver enzymes in hepatitis patients and role of interferon therapy as a progressive treatment in Pakistan. Methodology of the study: This cross sectional study was conducted at Shaikh Zayed Hospital, Lahore during September 2018 to January 2019. The data was collected from 200 patients of both genders who were suffering from hepatitis. The data was collected through a detailed questionnaire through which we collect the demographic data of patients. Blood investigation including Hemoglobin (Hb), total leucocytes count (TLC), differential leucocytes count (DLC), platelet count, X-ray chest, ultrasound abdomen and LFT were done in all patients. Results: The data were collected from 200 patients. The baseline characteristics of patients were recorded for the start of the treatment including age, blood complete picture, viral load and liver function test etc. The demographic values of patient group and control group shows a significant difference. The data suggest clearly that CD4 count decreases in abnormal liver function. There were non-significant relationship present in diseased group treated with different therapies like interferon and glutathione as p<0.05. Conclusion: It is concluded that hepatitis directly increase the liver enzymes even after receiving medication and other therapies.

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