ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

ANALYSIS OF BIOCHEMICAL MARKERS IN PATIENTS WITH HEPATITIS RESISTANT TO INTERFERON THERAPY

Dr Ayesha Aziz, Dr Afaq Sadaat, Dr Maria Nazar

Introduction: Hepatitis is a Latin word which means inflammation of liver. At the present time viral hepatitis is a major health problem worldwide, particularly in Asian countries. Hepatitis is caused by different hepatic viruses and it leads to liver related morbidity. Aims and objectives: The main objective of the study is to analyse the biochemical markers in patients with hepatitis resistant to interferon therapy. Material and methods: This cross sectional study was conducted in Combined Military Hospital, Rawalpindi during September 2018 to February 2019. The data was collected from 100 hepatitis patients of both genders. This study was aimed to analyse the biochemical markers in hepatitis patients. Blood sample was drawn for the analysis of serum biomarkers. Liver function test of all the selected patients was done by using enzymatic kit method. Serum micronutrients levels were also determined for all those patients who were resistant to interferon therapy. Results: The data was collected from 100 hepatitis patients. The mean age was 36.5 + 10.1 years and BMI of the patients was 21.7 ± 2.7 (kg/m2). The mean duration of HIV was 38 ± 43.8 months. There were non-significant relationship present in diseased group treated with different therapies like interferon and glutathione as as p<0.05. The level of micronutrients become decreases in diseased group. Conclusion: It is concluded that most of the patients of co-resistant HBV and HCV have decreased value of micronutrients and increased value of ALT and AST levels.

FULL TEXT