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IN PRIMARY HYPOTHYROIDISM ROLE OF THYROID HORMONE REPLACEMENT THERAPY ON LIPID PROFILE

Dr.Rimsha Khalid, Dr.Qaria Saira Irshad, Dr.Asadullah Sabir

Objective: To investigate the effect of thyroid hormone replacement therapy on lipid profile in primary hypothyroidism. Study Design:A Prospective and Observational Study. Place and Duration: In the Endocrinology Department of Services Hospital Lahore for One year duration from January 2018 to January 2019. Methods: Eighty subjects were included in this study. Forty patients (group of patients before G1 treatment) were each treated with increasing doses of "thyroxine" (50,100 and 150 g / day "doses set by the attending physician") to achieve a 20-day condition euthyroid. Thyroxine was administered as a maintenance dose of 100-150 / g / day for 30 days until fasting blood samples were taken from the same patients (patient group after G2 treatment). In the control group (CG Group), euthyroid individuals with age and sex were selected. We selected 40 individuals aged 18-40 years who were diagnosed with primary hypothyroidism (TSH> 10 μIu). Euthyroid age and gender and 40 control groups were selected as the control group. Subjects with diabetes mellitus and ischemic heart disease were excluded. We have also excluded those involved in any pharmacological treatment that may alter thyroid function and lipid metabolism. In the morning (0800-1000), 10 ml of antecubital venous blood samples were taken after fasting overnight (12-14 hours) and after half hour of supine rest. For thyroid profile, Serum sample was taken. Results: Serum T3 levels rised significantly in subjects with primary hypothyroidism after treatment compared to the pre-treatment group. Serum T4 rised significantly in primary hypothyroidism patients after treatment compared to the patient group. In primary hypothyroidism, Serum TSH levels decreased significantly after treatment compared to the patient group before treatment. Serum LDL-c,TC, TG levels showed a major decline in serum TG, LDL-c,TC, levels before treatment in patients with primary hypothyroidism after treatment. Conclusion: Our results showed beneficial effects of L-thyroxine on lipid profile of patients with primary hypothyroidism and showed a decrease in TG, LDL-c andTC levels after treatment. Key words: hypothyroidism, cholesterol, LDL.

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