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A PROSPECTIVE RESEARCH TO EXPLORE INTERVAL OF TLC NORMALIZATION WITH LEUKOPENIA TREATMENT

Dr Maryam Haroon

Objective: The objective of the research was to notice the TLC (Total leucocyte count) normalization interval with subsidiary G-CSF therapy in leukopenic newborn septic infection as well as comparison of the neutrophilic reaction to Granulocyte- colony-stimulating factor in neutropenic verses non-neutropenic subcategory. Material and Methods: The design of the research was a prospective cohort which was carried out at Mayo Hospital, Lahore from July 2017 to February 2018. The researcher selected only 51 neonatal having a septic infection as well as leucopenia out of 5666 neonatal hospitalized in NICU while research period. On the basis of ANC (absolute neutrophil count), the entire neonatal were divided into exposed (neutropenic) as well as unexposed (non-neutropenic) subcategories. Subsidiary G-CSF was provided to entire newborns of the research and disconnected once total leucocyte count normalized. The researcher utilized SPSS for measuring average G-CSF treatment interval and ascent in absolute neutrophil count. The computation of Pearson association coefficient, as well as in complex straight regression, was carried out to evaluate the association in pre-G-CSF, absolute neutrophil count, and treatment interval with granulocyte- colony-stimulating factor. Sub categories comparison with reference to ascent in the absolute neutrophil count was carried out by utilizing independent sample T-test. Results: The average granulocyte-colony-stimulating factor treatment interval was 1.82±0.81 days (1 to 4). The number of neutropenic newborns was twenty-five (49%). The Pearson association coefficient displayed a positive however slight as well as non-expressive connection in the 2 element (r = 0.070, n= 51 and P =0.625). An unimportant equation of regression was identified {F (1, 49) = 0.242, P =0.625} with R2 =0.005. There was a (7.06± 4.5) fold increase in absolute neutrophil count in neutropenic subcategory with respect to (4.5± 3.1) fold increase in the unexposed subcategory (P value= 0.04). Conclusion: The interval of fewer than two days is the average period for leukopenia retrieval with G-CSF therapy in newborn septic infection as well as had a substantial association with G-CSF ANC. In neutropenic newborn, the feedback of neutrophilic was considerably high with respect to non-neutropenic neonates. A G-CSF formed no variation to the findings in term of demise; its daily usage is not approved in leukopenic newborn septic infection. Keywords: Duration of Hospital Stay (LOS), MDG-4 (Millennium Developments Goals), ANC (Absolute Neutrophil Count), TLC (total Leucocyte Count), Granulocyte- Colony Stimulating Factor (GCS-F), STROBE (Strengthening the Reporting of Observational Studies in Epidemiology).

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