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A RANDOMIZED CONTROL TRIAL TO COMPARE THE EFFECTIVENESS OF CLOMIPHENE CITRATE AND LETROZOLE AMONG OVULATORY INFERTILE FEMALES

Dr Tayyaba Tahira, Dr Sana Nadeem, Dr. Rooma Qasim

Objectives: The objective of this study was to compare the effectiveness of clomiphene citrate and letrozole among ovulatory infertile females. Material and Methods: We carried out this randomized controlled trial at Jinnah Hospital, Lahore from October 2017 to June 2018 on a total of 224 ovulatory infertile females which were in the age bracket of 18 – 40 years. Results: We selected women in the age limit of 18 – 40 years which were divided into two main groups Group – A (Clomiphene Citrate) & B (Letrozole) with a respective mean age of (26.72 ± 6.02) years and (26.87 ± 6.33) years. Most dominant age bracket was 18 – 30 years among 148 patients (66.07%). Mean infertility duration was (3.47 ± 2.21) years; for Group – A & B the mean infertility duration was (3.23 ± 2.19) years and (3.68 ± 2.34) years. Group – A efficacy was reported in 19 patients (16.96%) and for Group – B among 37 patients (33.04%) (P-Value = 0.005). Conclusion: The outcomes conclude that Clomiphene Citrate is less effective than Letrozole in order to achieve pregnancy among ovulatory infertility females. Keywords: Ovulatory, Letrozole, Infertility, Clomiphene Citrate, Efficacy and Pregnancy.

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