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TITLE:

DIAGNOSIS AND TREATMENT OF PAROXYSMAL NOCTURNAL HEMOGLOBINURIA WITH COEXISTING APLASTIC ANEMIA IN A 37-YEAR OLD SAUDI MALE: A CASE REPORT WITH REVIEW OF LITERATURE

AUTHORS:

Fatemah A. Al-Dahneen, Mohammed S. Al-Hassan, Fatemah M. Al-Essa, Ali S. Al-Mutair, Gamal Ghanem Mohamed Mostafa, Sawsan A. Omer.

ABSTRACT:

Introduction: paroxysmal nocturnal hemoglobinuria (PNH) is a very rare acquired disorder of hematopoietic stem cells and a life threatening disease ; characterized by compliment mediated hemolytic anemia, thrombosis and impaired bone marrow function. There are only over 4000 patients in the international PNH registry. In this report we will describe a case of a Saudi male patient diagnosed with PNH. Case report: A 37 year old male patient presented to our hospital (King Fahad Hospital Hufof) with shortness of breath, palpitation and fatigability; on a background history of multiple prior presentations with red urine. His investigations showed non autoimmune hemolytic anemia and leucopenia . After an extensive work-up, he was found to have paroxysmal nocturnal hemoglobinuria with Aplastic Anemia which requires careful evaluation and management as it is associated with morbidity and mortality if not treated properly. Conclusion: Physicians needs high index of suspicion for the diagnosis of PNH to avoid serious complications of the disease. Key words: paroxysmal nocturnal hemoglobinuria, aplastic anaemia.

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