ResearcherID - CLICK HERE Scientific Journal Impact Factor (SJIF-2020) - CLICK HERE

THE COMPARISON OF ONE MEDICATION OF OMEPERPRAZOLE (20MG) WITH ESOMEPRAZOLE (40MG) FOR THE DIAGNOSIS OF GASTRIC ACIDITY

Dr Ezza Wasim, Dr Maryam Ramzan, Dr Maheen Zulfiqar

Objective: We aimed in this analysis to match and calculate the efficacy of one medication of omeprazole 20 mg and esomeprazole 40 mg on stomach. Study design: A comparative type of randomized case control study. Place and duration: This analysis was carried out in the operation theater of Mayo Hospital in Lahore after the verification by hospital ethics committee and IRB of King Edward Medical University Lahore for the duration of 6 months from June 2018 to December 2018. Material and Methods: Number of 50 patients of ASA class p1 and p2 condition were sorted in this analysis after taking written agreement form with the age ranging from 15 years to 60 years and body mass index BMI 20.0 kg to 35.0 kg per m2 suffering from inguinal hernia operation electively having both genders. Patients were separated by the number of 25 both into two groups named as group O and group E consisting omeprazole 20 mg and esomeprazole 40 mg respectively medicated to all patients of each group respectively before operation night at 10:00 pm and were suggested to stay at complete bowel rest. A multi-orifice nasogastric tube 16F was inserted in the stomach and proven by auscultation over the upper and median part of the abdomen, lying over the stomach by air 10 ml in the morning after the processing of usual anesthesia. Gastric liquid was collected in a sterile injection and forwarded in a sterile test tube. pH was examined through calibrated pH paper and was verified by pH meter. Nasogastric tube was then taken off. Results: The physical statistics of both groups were expressed like Average ± SD and remain significant in the groups definite as shown in table no 01 and table no 02. Median range of gastric liquid pH was 4.5 with the value between 1.5 to 7.0 in group O and 7.0 with the value between 3.0 to 8.0 in the group E as shown in table no 03 where the value of P was indefinite. Number and percentage of patients in danger that is 4 out of 25 patients at danger in group o and no case was observed at danger in group E as shown in figure A and the association of duration of premedication with the pH meter of group O was determined through figure B. No relevant variations of intragastric pH are observed through raising the time of premedication. Hence the outcomes persist slightly different. The duration of premedication was raised the intragastric pH persists mostly more than value of 2.5 in each patient as observed through the figure C. In the group O and Group E the average range of gastric liquid pH was 4.5 where range was 1.5 to 7.0 and 7.0 where range was 3.0 to 8.0 respectively. The value of P was indefinite. Conclusion: One medication of 40 mg Esomeprazole taken by mouth at the time of rest before operation has similar effectiveness in raising the intragastric pH as one medication of 20 mg Omeprazole taken by mouth. Key Words: Esomeprazole, omeprazole, Gastric pH, Medication, Anesthesia.

FULL TEXT