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TITLE:

ROLE OF PROLACTIN: A COMPARATIVE STUDY BETWEEN GRAND MAL EPILEPTIC AND PSEUDO-SEIZURES PATIENTS

AUTHORS:

Dr Avais Ahmad, Dr Farhat Ijaz, Dr Ambreen Tauseef, Dr. Rana Khurram Aftab, Dr Hira Sohail, Dr Rizwana Kamran, Prof Dr Samia Jawed and Musarrat Ijaz

ABSTRACT:

Background& Objectives:-Epilepsy is a condition of the brain characterized by abnormal, recurrent and excessive discharge from living neurons of brain. It comes in attacks or fits which lasts for a few seconds to a few minutes. It is important to distinguish generalized tonic-clonic seizures (GTCS) from either psychogenic non epileptic seizures (PNES).This study was designed to determine the level of prolactin hormone in females suffering from Grand Mal epilepsy and Pseudo seizures. Methodology: After getting approval from Ethical Review Board, this cross-sectional study was conducted in a tertiary care medical teaching hospital over a period of 2 years. Ninety female subjects were enrolled in our study and they were divided in three groups, each of which comprised of 30 subjects: Group-1: Patient with confirmed previous history of grand mal seizures and including freshly diagnosed cases of GTCS. (n=30) Group-2: Patient with history of pseudo seizures. (n=30)Group-3: Control group: Females of comparable age (n=30).Statistical analyses was done using SPSS 21. ANOVA was used to compare the results of the different groups. P< 0.001was taken as significant Results:- The results showed significant difference of serum prolactin levels among three groups (p value 0.0001). Serum prolactin level was higher in epileptic group as compared to pseudo-seizures and control group (p <0.001). Conclusion:- It is concluded that serum prolactin may be used as a sensitive biochemical marker in the diagnosis of grand mal seizures in females and is also helpful in differentiating it from pseudo-seizures Key words: Prolactin, Generalized Tonic-Clonic Seizures, Pseudo-Seizures

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