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TITLE:

ANALYSIS OF FREQUENCY OF MALIGNANT LESIONS OF AMPULLARY AND PERIAMPULLARY REGION IN PATIENTS WITH OBSTRUCTIVE JAUNDICE

AUTHORS:

Dr Abira Khan, Dr Bilal Waheed, Dr Maria Naseer

ABSTRACT:

Introduction: Ampullary lesion are common in male patients and in people above 60 years especially in heavy smokers, alcohol, coffee, high fat, high protein, low fruit and low vegetable intake. Objectives: The basic objective of the study is to analyse the frequency of malignant lesions of ampullary and periampullary region in patients with obstructive Jaundice. Material and methods: This cross-sectional study was conducted in Aziz Bhatti Shaheed Teaching Hospital, Gujrat from February 2018 till July 2018. Biopsy specimen of 94 patients was enrolled for the study using inclusion criteria. Sample size was estimated by using 5% level of significance with expected frequency of 57% ampullary carcinoma as reported by a study conducted on patients with ampullary masses, with 10% margin of error. The sample size calculated was 94 by using WHO calculator for single proportion. Results: Total 92 patients were included in this study. Mean age of all patients was 58.20±12.02 years. Mean age of male and female patients was 57.69±12.07 and 59.18±12.03 years respectively. Age range for male patients was 35-76 years and for female patients age range was 45-80 years. Conclusion: It is concluded that frequency of malignant lesions of ampullary and periampullary region in patients with obstructive Jaundice is quite high.

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