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ANALYSIS OF DIFFERENT BIOMARKERS FOR ORAL TONGUE SQUAMOUS CELL CARCINOMA (SCC) AMONG LOCAL POPULATION OF PAKISTAN

Dr Nabila Anber, Dr Maimoona Riaz, Dr Muhammad Abdullah Haris

Introduction: Oral tongue squamous cell carcinoma (OTSCC) is the most common malignancy of the oral cavity. OTSCC is increasing in incidence and has an aggressive clinical behaviour with a relatively poor prognosis. Objectives of the study: The basic aim of the study is to find some important biomarkers which are useful in the diagnosis and treatment of oral tongue squamous cell carcinoma (SCC) among local population of Pakistan. Material and methods: This cross-sectional study was conducted in Mayo Hospital Lahore in August 2017 till May 2018. The data was collected from 100 patients of OSCC. 5.0 cc blood sample was taken from vein. Blood was further processed for the estimation of serum biomarkers i.e Sialic acid, NO, Vita-A, Vit-E and GSH. Commercially available enzymatic kits of Randox were used. Blood was centrifuged at 4000 rpm for 10 minutes and serum was separated. Blood samples will be collected into EDTA tubes from fasting proteins. Results: The data was collected from 100 patients of both genders. The data represents that there is a statistical difference among control group and patients. The data shows all the expected prognostic markers which used for the assessment of OSC in humans. The values of GSH and SOD shows that these are the most important biomarkers for the analysis of OSC in humans. Blood samples shows the clear values of Vit-A, Vit-C, Vit-E, GSH, Catalase, SOD and MDA with the correlation of some micronutrients e.g zinc and iron. Conclusion: It is concluded that GSH, MDA and SOD are the important diagnostic biomarkers in the assessment of OSSC.

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