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ANALYSIS OF MECHANISM OF GENETIC POLYMORPHISMS AND ITS ASSOCIATION OF BLOOD TRANSFUSION IN ACUTE MYELOID LEUKEMIA AMONG LOCAL POPULATION OF PAKISTAN

Dr Chaudary Mohammad Awais, Dr Ishra Javed, Dr Zia ur Rehman

Introduction: Acute myeloid leukemia (AML) is a heterogeneous group of leukemias that result from the clonal transformation of a primitive stem/progenitor cell by more than one genetic aberration. Aims of the study: The main objective of the study is to analyze the mechanism of genetic polymorphisms and its association of blood transfusion in acute myeloid leukemia among local population of Pakistan. Methodology of the study: This descriptive study was conducted in PIMS, Islamabad during November 2018 to March 2019. The data was collected from histologically confirmed cases of AML. The age group for this data was 20 to 50 years. Participation of all the patients were voluntary and written consent was obtained from all participants. Those who want to participate and signed consent were interviewed by medical staff by using a standardized and structured questionnaire and personal interview. Results: The data was collected from 50 patients of AML. There is a positive correlation between blood transfusion and AML B-cells. Table 02 represents the data of both normal cases and AML patients. Conclusion: It is concluded that genetic polymorphism in TNF and IL10RA gene modifies the association between blood transfusion and risk of leukemia B-cells. Key words: Acute, Transfusion, Blood, Genes

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