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RELATIONSHIP OF HYPERBILIRUBINEMIA AND HYPOALBUMINEMIA WITH FIBROSCANIN VARIOUS STAGES OF FIBROSISIN RNA POSITIVEHCVINFECTEDPATIENTS

Azhar Hussain, Muhammad Salman, Zaboor Ahmad

Background:Hepatitis is a global problem affecting population of about 180 million worldwide with high prevalence rate in developing countries. In a report published by WHO in 2017,Hepatitis C is most prevalent in Egypt followed by Pakistan. Objectives :To determine the relationship between progressive stages of fibrosis and serum albumin & bilirubin level with fibroscan score and stages of fibrosis determined by fibrosacn score. Material and Methods: The retroprospective cross sectional study was conducted in medicine unit 1 and hepatitis clinic of Lahore General Hospital, Lahore starting from February 15, 2018 to January 11, 2019. We studied 1434HCV infected patients which were got CBC, LFTs, ELISA and fibro scan done to perfectly diagnose ongoing hepatitis C infection. In order to differentiate HCV fibrosis progression, we compared the relationship between progressive stages of fibrosis and serum albumin & bilirubin level. Results:A total of 1434 patients, comprising 552 men and 882 women, with mean age of 42 ±12 years, were enrolled. Of these, 736 (51.3%) have fibrosis stage F0-F1, 100 (7%) have F2, 196 (13.7%) have F3, and 402 (28%) have stage F4.By applying Independent sample T test, the relationship between stage of fibrosis predicted by Fibro Scan and albumin level was found to be non-significant (p>0.05). By applying Independent T test, it was found that serum bilirubin rise was not significantly correlated with the Fibro Scan stage F1-F2 (P>0.05). But stage F3-F4 showed a significant proportional correlation with rise in serum bilirubin level (P<0.05). Conclusion and Implications: Independent T test results showed that serum bilirubin rise was not significantly correlated with the Fibro Scan stage F1-F2 (P>0.05). But stage F3-F4 showed a significant proportional correlation with rise in serum bilirubin level (P<0.05) and albumin level wasfound to be non-significant in various stages (p>0.05).

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