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TITLE:

A REVIEW ON NEUROPATHIC PAIN: NEUROPROTECTIVE AGENT

AUTHORS:

Ms. Pallavi Rajendra Baviskar, Mr. Hitesh Vinayak Kachave, Mr.Wasil Kafeel Ansari, Ass. Prof. Patil Vinod

ABSTRACT:

Neuropathic pain may be spontaneous or evoked in response to physical stimuli that may manifest as increased sensitivity to pain hyperalgesia or as a pain evoked by a nonpainful stimuli allodyania. Chronic neuropathic pain is a common significant and depilating and problem that present challenge to health-care. Despite the multi-target of available drugs, there are no curative conventional treatments for neuropathic pain. A literature investigation was carried out by analyzing classical peer reviewed papers and textbooks, taking into consideration worldwide well established scientific databases mainly PUBMED and SCOPUS to retrieve accessible published literature. The selection of physiotherapies was based upon their potential in reliving NP in pre-clinical model. Diabetic mellitus is a metallic associated with structural and functional alteration of various organ system. The tissue injury is attributed to chronic hyperglycemia. Additionally, neuro-inflammation is a known factor in the development and maintenances of neuropathic pain. During neuropathic pain development, the c-c motif chemokine receptor 2|(CCR2)acts as an important signaling mediators. Key Words: Neuropathic pain, Diabeic neuropathy, model of neuropathic pain, Neuroprotective agent.

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