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ANALYSIS OF VITAMIN D LEVELS WITH BONE DENSITY AND ALKALINE PHOSPHATASE IN WOMEN

Dr Rameen Masood, Dr Lubna Mahek, Dr Hafiz Muhammad Umer Mehran

Introduction: Vitamin D deficiency causes defects of bone mineralization and low vitamin D status has been detected in patients with hip fractures. Aims and objectives: The basic aim of the study is to analyse the vitamin D levels with bone density and alkaline phosphatase in women. Material and methods: This cross sectional study was conducted in Services hospital, Lahore during November 2018 to March 2019. The data was collected from 100 patients. Patients with hyperparathyroidism, Paget's bone disease, or secondary osteoporosis were not included in the study. All clinically suspected cases of osteopenia and osteoporosis with age >40 years were included in this study. The data were collected through a questionnaire in which we add all the demographic values of selected patients. Results: The data was collected from 100 individuals. There was no significant correlation (P = 0.09) between values for 25-OHD and 25-(OH)2 D. Ten per cent of the women (n = 50) had serum 25-OHD levels below 12 ng mL. This subgroup also had significantly lower serum 25-(OH)2D (24.9 vs. 27.9 pg mL, P , 0.05), but they did not differ from the rest with regard to PTH and P-calcium levels. Conclusion: It is concluded that vitamin D deficiency causes bone loss and increased bone turnover and, therefore, vitamin D status should be assessed and corrected in populations at risk.

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