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STUDY TO REVEAL THE EFFICACY OF AMLODIPINE FOR THE TREATMENT OF ESSENTIAL HYPERTENTION AND ITS TOXICITY AND TOLERABILITY

Dr Arslan Hameed, Dr Abdul Azim, Dr Najeeburahman

Objective: To know the tolerability and efficacy of Amlodipne in the mild to moderate hypertension treatment. Study design: An Observational Study. Location and Duration: This study was conducted in medicine department of Jinnah hospital, Lahore for one year duration from December 2017 to December 2018. Methods: Eighty patients with ages ranging from 30 to 90 years were selected for the study. The mean age ± SD was 62.27 ± 8.19. After the history was taken, patients diagnosed with mild to moderate hypertension the antihypertensive drugs were given, but hypertension was not adequately controlled were selected. Diastolic blood pressure was defined as 90-112 mmHg in sitting position. It is based on two separate situations at least 6 days apart. A dose of 5 mg amlodipine was recommended and administered daily for at least 15 days. Two weeks later, the daily dose was adjusted to 10 mg in patients who did not show a satisfactory reduction in blood pressure in the absence of clinically significant side effects thought to be drug-related. The patients were followed-up for six weeks. Results: After six weeks of treatment, 30 mmHg was the decline in systolic blood pressure and the 20 mmHg decline in diastolic blood pressure. Fifty-nine (76%) patients received 5 mg, while the remaining 19 (24%) used 10 mg amlodipine. At the end of the study, patients did not show a significant change in heart rate. Overall, efficacy assessment was excellent at 78%, good at 18%, and fair at 4%. As for tolerance, it was excellent at 81%, good at 15%, fair at 3% and weak at 1%. 80 patients (14%) had a negative effect and 2 (3%) withdrew from the study due to adverse effects, one was a male patient after 2 weeks and the other was female 4 weeks later. Conclusion: This study concluded that amlodipine is effective once a day for mild to moderate hypertension. Key words: amlodipine, efficacy, essential hypertension.

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