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ASSOCIATION OF HYPOADIPONECTINEMIA TO A COMPLETE CHOLESTEROL TEST AND GLYCEMIC CONDITION IN FEMALES WITH TYPE 2 DIABETES IN THE PRESENCE AND ABSENCE OF CORONARY ARTERY DISEASE (CAD)

Dr Sidra Nisar, Dr Ghulam Ali Hasnan, Dr Salman Mahmood

Objective: We aimed in this analysis to observe the revolving adiponectin absorption in type 2 diabetic females in the presence and absence of coronary artery disease (CAD) and to develop an association of adiponectin intensity complete cholesterol test and glycemic condition of these females. Study Design: A cross sectional type of investigative analysis. Place and duration: This analysis was conducted in the Services Hospital, Lahore for the duration of one year from December 2017 to November 2018. The verification of this analysis was gained from Ethical Committee of Services Hospital, Lahore. Methodology: The analysis comprised of 74 female patients out of which 26 were with high blood sugar, 24 high blood sugar with coronary artery disease (CAD) and 24 were healthy. All the enrolled patients were sorted out casually. Blood samplings with fasting were gotten from the patients and observed for serum adiponectin intensity, fasting blood glucose (FBG), very low-density lipoprotein cholesterol (VLDL-C), Low density cholesterol (LDL-C), High density lipoprotein cholesterol (HDL-C), total cholesterol (TC), triglycerides (TG) and glycosylated hemoglobin (HbA1c) Results: The intensity of serum adiponectin and intensity of HbA1c and FBG was instantly minimum and maximum respectively where the value of P was less than 0.001 both found as a matching between type 2 high blood sugar female patients having presence and absence of coronary artery disease (CAD) and healthy women. Negative relativity of adiponectin with FBG where r was - 0.874, value of P was less than 0.01, r - 0.497, value of P was less than 0.01, Triglycerides where r was -0.669, value of P was less than 0.01, r - 0.790, value of P was less than 0.01, total cholesterol where r was - 0.423, value of P was 0.039, r - 0.733, value of was less than 0.01 and HbA1c where r was -0.937 , P value was less than 0.01, r - 0.814 , P value was less than 0.01 was observed in female participated patients of high blood sugar in the presence and absence of CAD. All three groups which were comprising of healthy females where r was 0.988 with value of P less than 0.01, type 2 high blood sugar with the presence of coronary artery disease where r was 0.775 with P value less than 0.01 and type 2 high blood sugar with the absence of coronary artery disease where r was 0.908 with the P value less than 0.01 shown an instant positive relativity of adiponectin. Conclusion: Intensity of serum adiponectin is significantly decreased in female patients of type 2 high blood sugar with the presence and absence of coronary artery disease. Furthermore, the hypoadiponectinemia in these female patients is associated with un-balanced glycemic condition and intensity of abnormal lipid profile throughout the flow. Key words: Lipid profile, Type 2 diabetes mellitus, Glycemic status, Adiponectin, coronary artery disease (CAD).

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