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TYPE 2 DIABETES MELLITUS AFTER GESTATIONAL DIABESTES: A META ANALYSIS STUDY

Dr. Malaika Rehmani, Dr. Kanza Yousaf, Dr. Faizan Rizwan

Increased risk of developing type 2 diabetes in women with who had gestational diabetes. A comprehensive systematic review and meta-analysis to assess the strength of association between these conditions and the effect of factors that might modify the risk. It is identified that cohort studies in which women who had developed type 2 diabetes after gestational diabetes were followed up from Embase and Medline. 20 studies were included in study that met our inclusion criteria. Included studies with 675 455 women and 10 859 type 2 diabetic events. Calculated and pooled unadjusted relative risks (RRs) with 95% CIs for each study using a random-effects model. Number of cases of type 2 diabetes, ethnic origin, and duration of follow-up, maternal age, body-mass index, and diagnostic criteria were analyzed as subgroup. In conclusion, gestational diabetes had an increased risk of developing type 2 diabetes AS compared with those who had a normoglycaemic pregnancy (RR 7·43, 95% CI 4·79–11·51) . Although the largest study (659 164 women; 9502 cases of type 2 diabetes) had the largest RR (12·6, 95% CI 12·15–13·19), RRs were generally consistent among the subgroups assessed. Key Words: Gestational Diabetes, Type 2 Diabetes, Diabetes Mellitus.

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