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TITLE:

ASSESSMENT OF PATHOLOGICAL FEATURES OF HODGKIN LYMPHOMA IN PAKISTANI POPULATION

AUTHORS:

Dr Muhammad Ijaz, Dr Maria Younas, Dr Iqra Javid, Dr Hussain Zia

ABSTRACT:

Introduction: Hodgkin Lymphoma (HL) is an uncommon tumour, although it is one of the more frequent malignancies in young people. Aims and objectives: The basic objective of the study is to analyze the pathological features of Hodgkin lymphoma in Pakistan. Material and methods: This study was conducted in Mayo hospital, Lahore during July 2018 till December 2018. The data was collected from 50 female patients who were suffering from this issue. The included patients were fully anonymised before accessing their files and the study was approved by the ethical committee of the Hospital. Demographic data, presenting symptoms, examination findings, mainly number and size of nodal and extranodal regions, routine laboratory and histopathology results, treatment plan, and treatment outcome were retrieved from patients’ records. Results: The data was collected from 50 female patients. In the current cohort, the majority (n = 99, 96.1%) of the patients presented with lymphadenopathy. The most common nodal sites involved were cervical and mediastinal. Histopathological examination of the LN revealed subtotal effacement of the nodal tissue by a diffuse proliferation of lymphoid cells intermixed with scattered histiocytes, plasma cells, and eosinophils. Conclusion: It is concluded that the associated risk features of the disease had a negative impact on survival rates; however, the associations did not reach statistically significant levels except for LDH.

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