::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

A COMPARATIVE STUDY OF PLATELET COUNTS BETWEEN H. PYLORI INFECTED AND UNINFECTED INDIVIDUALS

AUTHORS:

Aniqa Liaquat, Zulquernain Zahid, Faizan Maqsood

ABSTRACT:

Introduction: Immune thrombocytopenic purpura (ITP) can be associated with Helicobacter Pylori (H. Pylori) stomach infection, which in this case often leads to an improvement in platelet count, if not always. There are relatively few studies comparing platelet counts in infected H. pylori patients versus healthy individuals. Place and Duration: In the Medicine department of Bahawal Victoria Hospital, Bahawalpur for one-year duration from March 2019 to February 2020. Methods: We compared the platelet counts in 200 H. Pylori infected and 200 uninfected individuals during the upper part of the esophagus-gastroduodenoscopy in patients reporting to the gastrointestinal tract clinic with dyspepsia. H. Pylori positive and negative patients were comparable by age (35.89 ± 10.73 and 34.93 ± 11.31, respectively, P value: 0.3845). Twenty (10%) infected patients had platelets below Counts 1.5 × 106 / mm3 and 35 (17.5%) ranged between 1.5 and 2 × 106 / mm3 (1% and 5% respectively uninfected group, P value: 0.0001). In addition, all 20 patients with thrombocytopenia were over 45 years old age and persons with the lowest number were the oldest (in the sixth or seventh decade). Conclusion: Patients with H. pylori gastric infection have lower platelet counts when compared with uninfected individuals after the exclusion of secondary causes of thrombocytopenia. Most patients with fewer platelets are in their five to seven decades. Key words: Helicobacter Pylori, platelets, thrombocytopenia, ITP, advanced age.