::INDO AMERICAN JOURNAL OF PHARMACEUTICAL SCIENCES::

CODEN : IAJPBB
issn 2349-7750

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TITLE:

INCIDENCE OF DEFICIENCY OF VITAMIN-D AND ITS ASSOCIATION WITH THE SEVERITY OF LIVER DAMAGE IN THE PATIENTS SUFFERING FROM HCV INFECTION

AUTHORS:

Dr Muhammad Jawad, Dr Sana Ullah Khan, Dr Hafiz M. Hamza Arshad

ABSTRACT:

Objective: Role of Vitamin-D is very important in different infectious diseases. Among these diseases, infections of the liver are highly distinct. This research work was carried out for the determination of the status of Vitamin-D in patients with HCV infection and healthy controls. Methodology: We conducted this research work on 74 patients at CMH Lahore from August 2019 to December 2019. Fifty-one patients were positive for hepatitis C RNA-PCR. Additionally, we recruited 23 persons without any liver complication as healthy controls. We performed the HCV RNA-PCR by ARTUS & HCV QS-RGQ V-1. The measurement of the levels of Vitamin-D was carried out by chemiluminescence. We used SPSS V.23 for the statistical analysis of the collected information. Results: Average Vitamin-D level was low in the patients of HCV infection in both compensated & decompensated cirrhotic patients (26.850 ng/mL and 20.650 ng/mL, correspondingly) in comparison to the subjects of healthy controls (30.410 ng/mL). This research work showed sub-optimal Vitamin-D level in 76.50% patients of HCV infection. Insufficiency of Vitamin-D (21.0-29.0 ng/mL) was prevalent among controls (47.80%) as well as in the patients of HCV infection (39.20%) (P< 0.0010). Additionally, levels of Vitamin-D displayed an inverse relationship with severe conditions of the liver complications as 55.20% patients of decompensated cirrhosis were suffering from the deficiency of Vitamin-D as compared to the 13.60% patients with Vitamin-D deficiency in the group of compensated cirrhosis. (P<0.00010). Conclusion: Sub-optimal Vitamin-D levels are much prevalent in patients suffering from HCV infection in comparison to their controls. There is a direct association of the Vitamin-D deficiency with the disease severity. KEYWORDS: Cirrhosis, Compensated, Decompensated, Prevalent, Deficiency, Hepatitis, HCV, Infection, Vitamin-D.