Jam Ali Haider, Umaima Malik, Muhammad Numan
Objective: The study was conducted with the objective of performing a comparative study of injection ondansetron 8 mg I.V. with injection metoclopramide 10 mg I.V. in preventing post-operative vomiting in routine major gynecological surgeries. Methods: This randomized, double blinded study was conducted at Nishtar Hospital Multan from May to November 2019 on sixty patients of American Society of Anaesthesiologist (ASA) I and ASA II undergoing routine major gynecological surgery (Transabdominal Hysterectomy, laprotomy and cystectomy, tubal surgery) under general anesthesia. Either of the drug was diluted to 5 ml of normal saline and given intravenously prior to induction of anesthesia. The post-operative period of first 24 hours was divided into two phases, the early (0-6 hrs.) and late (6-24 hrs.). The frequencies of vomiting and requirement of rescue antiemetics in both groups were studied. The general characteristics of the patients in the two groups were similar. In both groups, induction, maintenance, duration of anesthesia as well as the type of surgery and opioids requirement were similar. The data recorded were statistically analyzed using Chi -square test and t – test using SPSS v25.0. Results: The comparison revealed the frequency of vomiting to be less in ondansetron group compared to metoclopramide group. Rescue antiemetics was given only once in ondansetron group patients, whereas the need of rescue antiemetics was eight times in the metoclopramide group. The difference was statistically significant (p=0.03). No unwanted effects were noticed in both groups. Conclusion: For the prevention of Post-Operative Nausea & Vomiting, ondansetron was found more effective than metoclopramide but it has to be evaluated further by larger clinical trials. Keywords: Antiemetics, vomiting, general anesthesia, gynaecological surgery.