Petrov Yu.A and Kupina A.D.
Abstract. Aim. The purpose of this study was to analyze the features of changes in the immune response both at the local and systemic levels in patients with chronic endometritis (CE). Assess the state of cellular and immune components of the immune system in women with CE. Materials and methods. The study reveals in detail the variability of immunological rearrangement in 450 women with different macrotypes of CE (hypoplastic, hyperplastic, mixed), both at the local and systemic levels, The following indicators were analyzed to assess the state of the immune system: T-lymphocytes (CD 3+), B-lymphocytes (CD 20+), T-helpers (CD 4+), NK-cells (CD 16+), cytotoxic T-cells (CD 8+), rFAS-CD 95+ (apoptosis receptor), phagocytosis activity of monocytes and neutrophils. The above parameters were evaluated in the control group - 65 women with an early reproductive loss in history, but without chronic endometritis. Results. During the study it was found out that the greatest decrease in resistance and inhibition of immunological rearrangement was observed in a cohort with a hyperplastic variant of CE. Hyperreactivity of the immune system was characteristic of women with mixed macrotypes. The pro-apoptotic orientation of changes, inhibition of cellular and humoral units were revealed in a cohort with hypoplastic macrotypes of CE. The role of persistent microbial pathogen in the development of immune deficiency was studied. The results of the study detail the importance of destructive-inflammatory, autoimmune processes, the imbalance of the cellular and humor parts of the immune system in the initiation and maintenance of CE. Keywords: chronic endometritis, immune response, macrotypes, immunological rearrangement, diagnostics.